Science and Technology Production
SAN2023 Annual Meeting - POTENTIAL NEUROPROTECTIVE EFFECT OF DDOX IN PARKINSON'S DISEASE MODELS: A NOVEL NON-ANTIBIOTIC DOXYCYCLINE DERIVATIVE WITH ALPHA-SYNUCLEIN ANTI-AGGREGATING PROPERTIES
Congress
Authorship:
Terán, MM ; TOMAS GRAU, RODRIGO HERNÁN ; Soliz Santander, SE ; Luna Mercado, A ; Ávila, C ; Raisman Vozari, R ; Figadère, B ; Ploper, D ; Chehín, RDate:
2023Publishing House and Editing Place:
SANSummary *
Parkinson´s disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons due to misfoldingand aggregation of a-synuclein (aS) protein. Although Doxycycline (DOX) showed potential to interfere with aS aggregation, its antibiotic activity confers alimitation for long-term treatments. Thus, we synthesized and tested a reduced form of DOX (DDOX) with weaker antibiotic activity but improvedneuroprotective and anti-aggregant qualities. Information provided by the agent in SIGEVAKey Words
Parkinson's diseaseTetracyclinea SynucleinDDOX