6,3'-Dinitroflavone: a high affinity ligand for the BZD-R with potent anxiolytic properties.

Producción CyT

Artículo

Autoría

MARDER, NORA MARIEL

Fecha

1995

Revista

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5 (pp. 2717-2720)

Resumen Información suministrada por el agente en SIGEVA

6,3’-Dinitroflavone (2) and 6,4’-dinitroflavone (3), prepared by direct nitration of flavone (1), were found to be ligands for the benzodiazepine receptor (BDZ-R). Compound 2, with a Ki= 12 nM, produced potent anxiolytic effects in mice at a dose of 1 mg/Kg.