1. CONICET
  2. S&T Productions
Science and Technology Production
6,3'-Dinitroflavone: a high affinity ligand for the BZD-R with potent anxiolytic properties.

Article

Authorship
MARDER, NORA MARIEL
Date
1995
Magazine
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 5 (pp. 2717-2720)
Summary Information provided by the agent in SIGEVA
6,3’-Dinitroflavone (2) and 6,4’-dinitroflavone (3), prepared by direct nitration of flavone (1), were found to be ligands for the benzodiazepine receptor (BDZ-R). Compound 2, with a Ki= 12 nM, produced potent anxiolytic effects in mice at a dose of 1 mg/Kg.