Microwave-assisted Döbner Synthesis of 2-Phenylquinoline-4carboxylic Acids and their Antiparasitic Activities

Producción CyT

Artículo

Autoría

MUSCIA, GISELA CELESTE

Fecha

2008

Editorial y Lugar de Edición

HeteroCorporation

Revista

JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 45 (pp. 611-614) HeteroCorporation

Resumen Información suministrada por el agente en SIGEVA

series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products, was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited moderate activity against Trypanosoma cruzi and another two re... series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products, was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited moderate activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum, respectively.

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Palabras Clave

2-PHENYLQUINOLIN-4-CARBOXILYC ACIDSMICROWAVEANTIPARASITICDOEBNER