Science and Technology Production
Article
Authorship
Date
2008
Publishing House and Editing Place
HeteroCorporation
Magazine
JOURNAL OF HETEROCYCLIC CHEMISTRY,
vol. 45
(pp. 611-614)
HeteroCorporation
Summary
Information provided by the agent in
SIGEVA
series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products, was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited moderate activity against Trypanosoma cruzi and another two re...
series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products, was developed via the Döbner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited moderate activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum, respectively.
Show more
Show less
Key Words
2-PHENYLQUINOLIN-4-CARBOXILYC ACIDSMICROWAVEANTIPARASITICDOEBNER