Producción CyT
Congreso
Autoría
Diaz Miranda E.N.
;
Grande M.V.
;
Sanchez S.S.
;
HONORE, STELLA MARIS
Fecha
2022
Editorial y Lugar de Edición
Scielo
ISSN
1667-5746
Resumen
Información suministrada por el agente en
SIGEVA
Nonalcoholic fatty liver disease (NAFLD), a component of the cardiometabolic syndrome, has emerged as one of the most common etiologies of chronic liver disease. NAFLD, is strongly associated with obesity and is characterized by an irregular deposition of triglycerides in hepatocytes and increased oxidative stress. Current management is rooted in attenuating the risk factors such as gradual weight loss through lifestyle modifications with a focus on nutrition and exercise. The roots of Smallant...
Nonalcoholic fatty liver disease (NAFLD), a component of the cardiometabolic syndrome, has emerged as one of the most common etiologies of chronic liver disease. NAFLD, is strongly associated with obesity and is characterized by an irregular deposition of triglycerides in hepatocytes and increased oxidative stress. Current management is rooted in attenuating the risk factors such as gradual weight loss through lifestyle modifications with a focus on nutrition and exercise. The roots of Smallanthus sonchifollus (yacon) have shown benefits for glucose control and body weight in obese rats. The present study was designed to investigate the efficacy of yacon flour in the treatment of high-fat diet (HFD)-induced NAFLD in rats. Male Wistar rats were fed a standard diet (CD) or HFD for 12 weeks and then were divided into the following groups: CD, HFD, and HFD plus yacon (680mg/kg/bw, HFDY), for 8 continuous weeks. NAFLD was examined in terms of body weight, lipid profiles, liver function markers, and histology. Our results showed that yacon flour supplementation significantly reduced HFD-induced body weight, hyperlipidemia, and intrahepatic lipid accumulation (p<0.05). Yacon also restored oxidative stress by reducing lipid peroxidation (p<0.05) and improving the antioxidant capacity in both serum and liver of HFD-fed rats. Furthermore, flour intake could effectively alleviate liver injury by reducing hepatocyte ballooning and the signs of inflammation. Our study indicated that yacon flour may be an effective dietary supplement for protecting the liver against the metabolic impact of HFD-feeding and preventing the progression of NAFLD by regulating lipid metabolism and reducing inflammation and oxidative stress.
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Palabras Clave
obesityliveryacon