Producción CyT
Artículo
Autoría
Montaldo, Laura Andrea
;
Gallo, Alicia
;
Rocha, Gabriela Fernanda
;
Csernoch, Cecilia Edith
;
DE MARZI, MAURICIO CESAR
;
GUERRA, LILIANA NOEMI
Fecha
2023
Editorial y Lugar de Edición
Newlands Press
Revista
Therapeutic Delivery,
vol. 14
(pp. 675-687)
- ISSN 2041-5990
Newlands Press
Newlands Press
ISSN
2041-5990
Resumen
Información suministrada por el agente en
SIGEVA
Aim: Obesity is a chronic pathology of epidemic proportions. Mature adipocytes from a 3T3-L1 cell line were used as in vitro obesity model to test different bioactive compounds. We aim to evaluate cassis (Ribes nigrum) extract antioxidant activity and its antiadipogenic effect on mature adipocytes. Results: We produced an extract by using enzyme that combines cellulase and pectinase; we obtained high yield of the bioactive compound anthocyanin. Extract showed high antioxidant capacity. We condu...
Aim: Obesity is a chronic pathology of epidemic proportions. Mature adipocytes from a 3T3-L1 cell line were used as in vitro obesity model to test different bioactive compounds. We aim to evaluate cassis (Ribes nigrum) extract antioxidant activity and its antiadipogenic effect on mature adipocytes. Results: We produced an extract by using enzyme that combines cellulase and pectinase; we obtained high yield of the bioactive compound anthocyanin. Extract showed high antioxidant capacity. We conducted in vitro assays by adding the extract to adipocytes culture medium. Extract reduced intracellular levels of triglyceride by 62% and cholesterol by 32%. Conclusion: Enzymatic extract’s high antioxidant activity was likely attributable to its high concentration of anthocyanin. This extract inhibits lipid accumulation in adipocytes.
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Palabras Clave
ADIPOCYTESANTIOXIDANTSANTHOCYANINOBESITY
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