Oxidation of ?-Trifluoromethyl and Nonfluorinated Secondary Alcohols to Ketones Using a Nitroxide Catalyst

Artículo

Autoría

POLITANO, FABRIZIO ; Brydon, William P. ; Leadbeater, Nicholas E.

Fecha

2022

Editorial y Lugar de Edición

GEORG THIEME VERLAG KG

Revista

SYNTHESIS-STUTTGART, vol. 55 (pp. 1517-1524) GEORG THIEME VERLAG KG

Resumen Información suministrada por el agente en SIGEVA

A methodology for the oxidation of E-trifluoromethyl alcohols to the corresponding trifluoromethyl ketones is presented. A catalytic quantity of a nitroxide is used, and potassium persulfate serves as the terminal oxidant. The methodology proves effective for aromatic, heteroaromatic, and conjugated alcohol substrates. It can be extended to nonfluorinated secondary alcohols and, in this case, can be applied to a range of aromatic, heteroaromatic, and aliphatic alcohols.

Palabras Clave

ALCOHOLSPERSULFATEOXIDATIONNITROXIDEKETONESTRIFLUOROMETHYL KETONES

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http://hdl.handle.net/11336/226695