Science and Technology Production
Article
Authorship
POLITANO, FABRIZIO
;
Brydon, William P.
;
Leadbeater, Nicholas E.
Date
2022
Publishing House and Editing Place
GEORG THIEME VERLAG KG
Magazine
SYNTHESIS-STUTTGART,
vol. 55
(pp. 1517-1524)
GEORG THIEME VERLAG KG
Summary
Information provided by the agent in
SIGEVA
A methodology for the oxidation of E-trifluoromethyl alcohols to the corresponding trifluoromethyl ketones is presented. A catalytic quantity of a nitroxide is used, and potassium persulfate serves as the terminal oxidant. The methodology proves effective for aromatic, heteroaromatic, and conjugated alcohol substrates. It can be extended to nonfluorinated secondary alcohols and, in this case, can be applied to a range of aromatic, heteroaromatic, and aliphatic alcohols.
Key Words
ALCOHOLSPERSULFATEOXIDATIONNITROXIDEKETONESTRIFLUOROMETHYL KETONES
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