Producción CyT
Artículo
Autoría
Gómez-Bouzó, Uxía
;
Belorusova, Anna Y.
;
Rivadulla, Marcos L.
;
Santalla, Hugo
;
Verlinden, Lieve
;
Verstuyf, Annemieke
;
Ferronato, Maria J
;
Curino, Alejandro C.
;
FACCHINETTI, MARIA MARTA
;
Fall, Yagamare
;
Gómez, Generosa
;
Rochel, Natacha
Fecha
2023
Editorial y Lugar de Edición
ACADEMIC PRESS INC ELSEVIER SCIENCE
Revista
BIOORGANIC CHEMISTRY,
vol. 136
ACADEMIC PRESS INC ELSEVIER SCIENCE
Resumen
Información suministrada por el agente en
SIGEVA
Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D3. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D3 with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D3, the 25-amino derivative being the m...
Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D3. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D3 with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D3, the 25-amino derivative being the most potent one while being less calcemic than 1,25-dihydroxyvitamin D3. The in vivo properties of the compounds make them of potential therapeutic value.
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Palabras Clave
VDRANALOGSVITAMIN DBIOLOGICAL ACTIVITY