Science and Technology Production
Article
Authorship
Gómez-Bouzó, Uxía
;
Belorusova, Anna Y.
;
Rivadulla, Marcos L.
;
Santalla, Hugo
;
Verlinden, Lieve
;
Verstuyf, Annemieke
;
Ferronato, Maria J
;
Curino, Alejandro C.
;
FACCHINETTI, MARIA MARTA
;
Fall, Yagamare
;
Gómez, Generosa
;
Rochel, Natacha
Date
2023
Publishing House and Editing Place
ACADEMIC PRESS INC ELSEVIER SCIENCE
Magazine
BIOORGANIC CHEMISTRY,
vol. 136
ACADEMIC PRESS INC ELSEVIER SCIENCE
Summary
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Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D3. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D3 with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D3, the 25-amino derivative being the m...
Intense synthetic efforts have been directed towards the development of noncalcemic analogs of 1,25-dihydroxyvitamin D3. We describe here the structural analysis and biological evaluation of two derivatives of 1,25-dihydroxyvitamin D3 with modifications limited to the replacement of the 25-hydroxyl group by a 25-amino or 25-nitro groups. Both compounds are agonists of the vitamin D receptor. They mediate biological effects similar to 1,25-dihydroxyvitamin D3, the 25-amino derivative being the most potent one while being less calcemic than 1,25-dihydroxyvitamin D3. The in vivo properties of the compounds make them of potential therapeutic value.
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Key Words
VDRANALOGSVITAMIN DBIOLOGICAL ACTIVITY