1. CONICET
  2. Comunidad CONICET
  3. LIONEL IVAN MULLER IGAZ
Comunidad CONICET
MULLER IGAZ, LIONEL IVAN

Investigador independiente

Especialidad
Neurociencias
Disciplina Científica
Ciencias Médicas
Tema
Nuevas estrategias terapéuticas en enfermedades neurodegenerativas: claves a partir de modelos preclínicos de proteinopatías de TDP-43
Lugar de Trabajo
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY (IFIBIO HOUSSAY, CONICET-UBA)
Depende de
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Dirección:
PARAGUAY 2155, piso 7, 1121 - Capital Federal - Argentina
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Resumen Información suministrada por el agente en SIGEVA
I contributed in establishing the existence of different time periods of transcription necessary for memory consolidation, as well as the role of mRNA and protein synthesis during memory extinction and persistence. Later I studied the role of the protein TDP-43 in neurodegenerative disease initially characterizing the different TDP-43 pathological species found in the patients with TDP-43 proteinopathies such as FTD and ALS, finding regional differences in inclusion composition. I also focused ... I contributed in establishing the existence of different time periods of transcription necessary for memory consolidation, as well as the role of mRNA and protein synthesis during memory extinction and persistence. Later I studied the role of the protein TDP-43 in neurodegenerative disease initially characterizing the different TDP-43 pathological species found in the patients with TDP-43 proteinopathies such as FTD and ALS, finding regional differences in inclusion composition. I also focused on developing cellular models that recapitulate the disease process through expression of different TDP-43 species. In parallel, I developed novel TDP-43 transgenic animal models with expression of different forms of TDP-43. We recently described a thorough behavioral characterization of the transgenic mouse expressing the cytoplasmic form of TDP-43, showing motor, cognitive and social changes that recapitulate those seen in FTD/ALS. I am now pursuing different lines of research integrating multidisciplinary approaches (including behavioral, pharmacological, biochemical and molecular studies).
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Líneas de Investigación

cambios celulares debido a la proteina TDP-43

Ciencias naturales y exactas

  • Ciencias biológicas
  • Biología celular, microbiología

rol de TDP-43 en el sistema nervioso central

Ciencias médicas y de la salud

  • Medicina básica
  • Neurociencias (incluye psicofiosiología)

Bioquimica de las enfermedades neurodegenerativas

Ciencias naturales y exactas

  • Ciencias biológicas
  • Bioquímica y biología molecular (ídem 3.1.10)
Capacidades Tecnológicas

6 - Ciencias biológicas

6.1 - Medicina, Salud humana

  • 6.1.12 - Neurología, investigación cerebral

6.2 - Biología / Biotecnología

  • 6.2.1 - Bioquímica / biofísica
  • 6.2.2 - Biología celular y molecular
Palabras Clave
NEURODEGENERATIVE DISEASESNEUROCIENCIA DE LA CONDUCTAENFERMEDADES NEURODEGENERATIVASPROTEINOPATIAS DE TDP-43TDP-43 PROTEINOPATHIESBEHAVIORAL NEUROSCIENCE
Formación Académica

2006 - 2010

Postdoctoral Fellow

University of Pennsylvania

2000 - 2005

Doctor de la Universidad de Buenos Aires

UNIVERSIDAD DE BUENOS AIRES

1992 - 2000

Licenciado en Ciencias Biológicas

UNIVERSIDAD DE BUENOS AIRES

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