1. CONICET
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  3. LIONEL IVAN MULLER IGAZ
CONICET Community
MULLER IGAZ, LIONEL IVAN

Independent researcher

Speciality
Neurociencias
Scientific discipline
Medical Sciences
Topic
Novel Therapeutic Strategies in Neurodegenerative Diseases: Insights from Preclinical Models of TDP-43 Proteinopathies
Workplace
INSTITUTO DE FISIOLOGIA Y BIOFISICA BERNARDO HOUSSAY (IFIBIO HOUSSAY, CONICET-UBA)
Dependencies
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Address:
PARAGUAY 2155, piso 7, 1121 - Capital Federal - Argentina
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Summary Information provided by the agent in SIGEVA
I contributed in establishing the existence of different time periods of transcription necessary for memory consolidation, as well as the role of mRNA and protein synthesis during memory extinction and persistence. Later I studied the role of the protein TDP-43 in neurodegenerative disease initially characterizing the different TDP-43 pathological species found in the patients with TDP-43 proteinopathies such as FTD and ALS, finding regional differences in inclusion composition. I also focused ... I contributed in establishing the existence of different time periods of transcription necessary for memory consolidation, as well as the role of mRNA and protein synthesis during memory extinction and persistence. Later I studied the role of the protein TDP-43 in neurodegenerative disease initially characterizing the different TDP-43 pathological species found in the patients with TDP-43 proteinopathies such as FTD and ALS, finding regional differences in inclusion composition. I also focused on developing cellular models that recapitulate the disease process through expression of different TDP-43 species. In parallel, I developed novel TDP-43 transgenic animal models with expression of different forms of TDP-43. We recently described a thorough behavioral characterization of the transgenic mouse expressing the cytoplasmic form of TDP-43, showing motor, cognitive and social changes that recapitulate those seen in FTD/ALS. I am now pursuing different lines of research integrating multidisciplinary approaches (including behavioral, pharmacological, biochemical and molecular studies).
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Lines of Investigation

cambios celulares debido a la proteina TDP-43

Natural and exact sciences

  • Biological sciences
  • Cell biology, microbiology

rol de TDP-43 en el sistema nervioso central

Medical and health sciences

  • Basic medicine
  • Neurosciences (includes psychophysiology)

Bioquimica de las enfermedades neurodegenerativas

Natural and exact sciences

  • Biological sciences
  • Biochemistry and molecular biology (same as 3.1.10)
Technological Capacities

6 - Biological sciences

6.1 - Medicine, Human Health

  • 6.1.12 - Neurology, Brain Research

6.2 - Biology/Biotechnology

  • 6.2.1 - Biochemistry/Biophysics
  • 6.2.2 - Cellular and Molecular Biology
Key Words
NEURODEGENERATIVE DISEASESNEUROCIENCIA DE LA CONDUCTAENFERMEDADES NEURODEGENERATIVASPROTEINOPATIAS DE TDP-43TDP-43 PROTEINOPATHIESBEHAVIORAL NEUROSCIENCE
Education

2006 - 2010

Postdoctoral Fellow

University of Pennsylvania

2000 - 2005

Doctor de la Universidad de Buenos Aires

UNIVERSIDAD DE BUENOS AIRES

1992 - 2000

Licenciado en Ciencias Biológicas

UNIVERSIDAD DE BUENOS AIRES

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