Comunidad CONICET
CARVELLI, FLAVIA LORENA

Investigadora adjunta

Especialidad
Biología Celular - Transporte Intracelular - Biología de la Reproducción
Disciplina Científica
Bioquímica y Biología Molecular - Biología
Tema
Estudio del sistema endosomal-lisosomal en diferentes modelos biológicos
Lugar de Trabajo
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS (IHEM, CONICET-UNCU)
Depende de
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Dirección:
EDIFICIO IHEM CENTRO UNIVERSITARIO S/N, M5502JMA - Mendoza - Argentina
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Resumen Información suministrada por el agente en SIGEVA
I studied mutations of the BRCA1 and BRCA2 genes of healthy women with a familiar history of breast cancer. I received training on mismatched PCR, use of restriction enzymes and Southern blot analysis. Subsequently, I investigated the DNA state of neoplasic cervix cells infected by HPV and collaborated in the detection of HPV (supported by the PAHO and the IARC). I received training in cell culture, PCR techniques and use of restriction enzymes. Later, I examined the mechanism of lysosomal prot... I studied mutations of the BRCA1 and BRCA2 genes of healthy women with a familiar history of breast cancer. I received training on mismatched PCR, use of restriction enzymes and Southern blot analysis. Subsequently, I investigated the DNA state of neoplasic cervix cells infected by HPV and collaborated in the detection of HPV (supported by the PAHO and the IARC). I received training in cell culture, PCR techniques and use of restriction enzymes. Later, I examined the mechanism of lysosomal protein secretion by epididymal epithelial cells (in vitro and in vivo). Moreover, I studied the mannose-6-phosphate receptor and its ligands during the perinatal development of several organs of the rat. I acquired expertise in cell culture, RT-PCR, confocal-immunomicroscopy, pulse chase analysis, immunohystochemistry, light and electronic microscopy, co-immunoprecipitation and immunoblotting. Currently, I am studying the molecular mechanisms of several epididymal lysosomal proteins on sperm maturation, capacitation and fertilization.
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Líneas de Investigación

Biología celular del epidídimo y su relación con la maduración espermática

Ciencias naturales y exactas

  • Ciencias biológicas
  • Biología reproductiva (aspectos médicos van en 3 ciencias médicas y de la hídrico salud)
Capacidades Tecnológicas

6 - Ciencias biológicas

6.2 - Biología / Biotecnología

  • 6.2.1 - Bioquímica / biofísica
  • 6.2.2 - Biología celular y molecular
  • 6.2.4 - Ensayos in vitro, experimentos
Palabras Clave
maduración espermáticaepidídimolysosomal enzymesepididymisenzimas lisosomalessperm maturation
Formación Académica

2004 - 2010

Doctora en Ciencias Biológicas

UNIVERSIDAD NACIONAL DE CUYO

1996 - 2003

Licenciada en Biología Molecular

UNIVERSIDAD NACIONAL DE SAN LUIS

Formación de RRHH
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