1. CONICET
  2. CONICET Community
  3. FLAVIA LORENA CARVELLI
CONICET Community
CARVELLI, FLAVIA LORENA

Adjunctive researcher

Speciality
Biología Celular - Transporte Intracelular - Biología de la Reproducción
Scientific discipline
Biochemistry and Molecular Biology - Biology
Topic
The endosomal-lysosomal system in different biological models.
Workplace
INSTITUTO DE HISTOLOGIA Y EMBRIOLOGIA DE MENDOZA DR. MARIO H. BURGOS (IHEM, CONICET-UNCU)
Dependencies
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Address:
EDIFICIO IHEM CENTRO UNIVERSITARIO S/N, M5502JMA - Mendoza - Argentina
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Summary Information provided by the agent in SIGEVA
I studied mutations of the BRCA1 and BRCA2 genes of healthy women with a familiar history of breast cancer. I received training on mismatched PCR, use of restriction enzymes and Southern blot analysis. Subsequently, I investigated the DNA state of neoplasic cervix cells infected by HPV and collaborated in the detection of HPV (supported by the PAHO and the IARC). I received training in cell culture, PCR techniques and use of restriction enzymes. Later, I examined the mechanism of lysosomal prot... I studied mutations of the BRCA1 and BRCA2 genes of healthy women with a familiar history of breast cancer. I received training on mismatched PCR, use of restriction enzymes and Southern blot analysis. Subsequently, I investigated the DNA state of neoplasic cervix cells infected by HPV and collaborated in the detection of HPV (supported by the PAHO and the IARC). I received training in cell culture, PCR techniques and use of restriction enzymes. Later, I examined the mechanism of lysosomal protein secretion by epididymal epithelial cells (in vitro and in vivo). Moreover, I studied the mannose-6-phosphate receptor and its ligands during the perinatal development of several organs of the rat. I acquired expertise in cell culture, RT-PCR, confocal-immunomicroscopy, pulse chase analysis, immunohystochemistry, light and electronic microscopy, co-immunoprecipitation and immunoblotting. Currently, I am studying the molecular mechanisms of several epididymal lysosomal proteins on sperm maturation, capacitation and fertilization.
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Lines of Investigation

Biología celular del epidídimo y su relación con la maduración espermática

Natural and exact sciences

  • Biological sciences
  • Reproductive biology (medical aspects go in 3 medical and health sciences)
Technological Capacities

6 - Biological sciences

6.2 - Biology/Biotechnology

  • 6.2.1 - Biochemistry/Biophysics
  • 6.2.2 - Cellular and Molecular Biology
  • 6.2.4 - In vitro Testing, Trials
Key Words
maduración espermáticaepidídimolysosomal enzymesepididymisenzimas lisosomalessperm maturation
Education

2004 - 2010

Doctora en Ciencias Biológicas

UNIVERSIDAD NACIONAL DE CUYO

1996 - 2003

Licenciada en Biología Molecular

UNIVERSIDAD NACIONAL DE SAN LUIS

HR Training
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