Science and Technology Production
Congress
Authorship
POLITANO, FABRIZIO
;
Leadbeater, Nicholas E.
Date
2021
Publishing House and Editing Place
Elsevier
Summary
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SIGEVA
Recently, we have generated a library of over 40 novel benzimidazole N-oxidecompounds in a two-step one-pot protocol. This class of compound shows biologicalactivity against some neglected tropical diseases (NTDs), making approaches to theirsynthesis particularly pertinent. Our methodology offer a greener alternative than thosepreviously reported as it uses only water and ethanol as solvents. Moreover, with asimple modification in the work-up, we could avoid liquid-liquid extraction and columnc...
Recently, we have generated a library of over 40 novel benzimidazole N-oxidecompounds in a two-step one-pot protocol. This class of compound shows biologicalactivity against some neglected tropical diseases (NTDs), making approaches to theirsynthesis particularly pertinent. Our methodology offer a greener alternative than thosepreviously reported as it uses only water and ethanol as solvents. Moreover, with asimple modification in the work-up, we could avoid liquid-liquid extraction and columnchromatography; product isolation being achieved by pH-dependent precipitation. Herepresent an assessment of our protocol using different simple sustainability metrics, suchas E-factor, CHEM21, EcoScale, Dozn, and Green Star.
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Key Words
BENZIMIDAZOLE N-OXIDESGREEN METRICSGREEN CHEMISTRYMICROWAVES