Science and Technology Production
Congress
Authorship
Serra Barcellona C.
;
HONORE, STELLA MARIS
;
Habib N.C.
;
Sanchez S.S.
;
Genta S.B.
Date
2014
Publishing House and Editing Place
Inca
ISSN
0327-9545
Summary
Information provided by the agent in
SIGEVA
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia. Yacon (Smallanthus sonchifolius) is an Andean crop used in traditional medicine. In our laboratory we demonstrated that leaves decoction and its main lactone enhydrin were effective in reducing blood glucose levels and useful in the treatment of diabetic animals. The present study was undertaken to evaluate the effect of Yacon leaf extract and enhydrin on the endocrine pancreas to establish one of its possible mech...
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia. Yacon (Smallanthus sonchifolius) is an Andean crop used in traditional medicine. In our laboratory we demonstrated that leaves decoction and its main lactone enhydrin were effective in reducing blood glucose levels and useful in the treatment of diabetic animals. The present study was undertaken to evaluate the effect of Yacon leaf extract and enhydrin on the endocrine pancreas to establish one of its possible mechanisms of action. The decoction and enhydrin were given to diabetic rats for 30 days at a daily dose of 140 mg/kg b.w. and 0.8 mg/kg b.w., respectively. Blood glucose, glycosylated hemoglobin (HbA1C) and insulin levels were determined in plasma. Immunohistochemical studies were performed on pancreas of diabetic animals with anti-insulin antibody. Oral administration of decoction and enhydrin resulted in a significant decrease in blood glucose and HbA1c levels at end of the treatment. Immunohistochemical studies revealed that treatment produced a significant increase in b-cell numbers. However, no changes were detected in plasma insulin levels during the experimental period. Our results suggest that Yacon leaf decoction and enhydrin improves the diabetic state by increasing the mass of positive insulin cells in the pancreas.
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Key Words
enhydrindiabetesyacon