Science and Technology Production
Article
Authorship
CHECA, SUSANA KARINA
;
Giri, German Francisco
;
ESPARIZ, MARTIN
;
Argüello, José M.
;
SONCINI, FERNANDO CARLOS
Date
2021
Publishing House and Editing Place
ELSEVIER SCIENCE LONDON
Magazine
TRENDS IN MICROBIOLOGY,
vol. 29
(pp. 384-387)
ELSEVIER SCIENCE LONDON
Summary
Information provided by the agent in
SIGEVA
Copper (Cu) plays a key role at the host–pathogen interface as both an essential element and a toxic element. Intracellular strains of pathogenic Salmonella have acquired the periplasmic Cu chaperone, CueP, and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Coregulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.
Key Words
ENTEROPATHOGENSCUEP AND CUSCOPPERBACTERIAL ENVELOPEHOST–PATHOGEN INTERACTION
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