Penfigoide ocular cicatrizal: Manifestaciones clínicas, diagnóstico y manejo actual

Article

Authorship

Schlaen, Bernardo Ariel ; Montoya, Juliana ; Heredia, Milagros ; Ficoseco, Carla ; DOMINGUEZ, LUCIA

Date

2022

Publishing House and Editing Place

Arhketypo

Magazine

AUTOINMUNIDAD, vol. 5 (pp. 114-120) - ISSN 2545-6032
Arhketypo

ISSN

2545-6032

Summary Information provided by the agent in SIGEVA

Ocular cicatricial pemphigoid is a progressive, bilateral, chronic disease, of autoimmune etiology, in which autoantibody deposits are observed in mucosal basement membranes. It is regarded as a mucous membrane pemphigoid subtype, a bullous dermatitis, characterized by blistering in mucosal tissues of nose, mouth, respiratory tract, and genitalia. As a counterpart, ocular involvement without systemic manifestations is observed up to one third of the patients. Ophthalmological presentation is as... Ocular cicatricial pemphigoid is a progressive, bilateral, chronic disease, of autoimmune etiology, in which autoantibody deposits are observed in mucosal basement membranes. It is regarded as a mucous membrane pemphigoid subtype, a bullous dermatitis, characterized by blistering in mucosal tissues of nose, mouth, respiratory tract, and genitalia. As a counterpart, ocular involvement without systemic manifestations is observed up to one third of the patients. Ophthalmological presentation is asymmetric, with a conjunctival inflammation which evolves to fibrosis, leading to an ocular surface insufficiency, and infectious and inflammatory complications, as well as a potentially devastating visual loss. A timely diagnosis, with an interdisciplinary approach and a suitable systemic treatment, are pivotal and they require a high level of experience, since this condition may be extremely difficult in identifying and treating.