Producción CyT
Capítulo de Libro
Autoría
Fecha
2011
Editorial y Lugar de Edición
Wiley
Libro
Encyclopedia of Reagents for Organic Synthesis
(pp. 1-3)
Wiley
Wiley
ISBN
9780470842898
Resumen
Información suministrada por el agente en
SIGEVA
Trimethyltin hydroxide (TMTOH) has proven to be a very efficient reagent for the saponification of nonhindered alkyl esters under mild conditions. Compared to classical saponification agents (LiOH, NaOH, K2CO3, Ba(OH)2, Cs2CO3, etc.), TMTOH is less prone to produce epimerization of sensitive stereocenters, or lead to the degradation of base-sensitive functional groups. In fact, the appearance of this very convenient hydrolytic reagent has led to a widespread use of methyl esters for the protect...
Trimethyltin hydroxide (TMTOH) has proven to be a very efficient reagent for the saponification of nonhindered alkyl esters under mild conditions. Compared to classical saponification agents (LiOH, NaOH, K2CO3, Ba(OH)2, Cs2CO3, etc.), TMTOH is less prone to produce epimerization of sensitive stereocenters, or lead to the degradation of base-sensitive functional groups. In fact, the appearance of this very convenient hydrolytic reagent has led to a widespread use of methyl esters for the protection of carboxylic acids.
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Palabras Clave
ethyl estersmethyl esterssaponificationResin Supported Esters