Metvan, bis(4,7-Dimethyl-1,10-phenanthroline)sulfatooxidovanadium(IV): DFT and Spectroscopic Study—Antitumor Action on Human Bone and Colorectal Cancer Cell Lines

Artículo

Autoría

LEON, IGNACIO ESTEBAN ; Ruiz, Maria Carolina ; Franca, Carlos Alberto ; Parajón Costa, Beatriz Susana ; Baran, Enrique José

Fecha

2019

Editorial y Lugar de Edición

Humana Press

Revista

BIOLOGICAL TRACE ELEMENT RESEARCH, vol. 191 (pp. 81-87) Humana Press

Resumen Información suministrada por el agente en SIGEVA

The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cyto... The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma (HT-29) cell lines. The results show that Metvan impaired cell viability of both cancer cell lines in a low concentration range (0.25–5.0 ?M).

Ver más Ver menos

Palabras Clave

DFT CALCULATIONSOXIDOVANADIUM(IV)METVANHUMAN BONE AND COLORECTAL CANCER CELL LINESFTIR SPECTRUM

Descargue o solicite el texto completo

http://hdl.handle.net/11336/93261