Spontaneous catanionic vesicles formed by the interaction between an anionic ?-cyclodextrins derivative and a cationic surfactant

Artículo

Autoría:

SILVA, OSCAR FERNANDO ; Hoyos, Maria Rita Micaela ; CORREA, NESTOR MARIANO ; Silber, Juana J. ; FALCONE, RUBEN DARIO

Fecha:

2018

Editorial y Lugar de Edición:

Royal Society of Chemistry

Revista:

RSC Advances, vol. 8 (pp. 12535-12539) - ISSN 2046-2069
Royal Society of Chemistry

ISSN:

2046-2069

Resumen

The present work shows the synthesis of a new type of catanionic surfactant, ModCD14-BHD, which involves an anionic amphiphilic cyclodextrin and the cationic benzyl-n-hexadecyldimethylammonium (BHD). It is obtained from the simple association of the cationic surfactant benzyl-n-hexadecyldimethylammonium chloride (BHDC) and ?-cyclodextrin (?-CD) monosubstituted with an alkenyl succinate group (Mod-?-CD14). ModCD14-BHD form unilamellar vesicles spontaneously in water, while the individual components (BHDC and Mod-?-CD14) do not. The vesicles were character-ized by dynamic light scattering (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and 1H NMR techniques. We suggest that the formation of an inclusion complex between some of the cyclodextrins units and the long hydrocarbon moiety of the cationic surfactant play a crucial role in the vesicles formation. Besides, some or the cavities are available to interact with an external guest. We think that the new surfactant molecule has properties that may lead to important applications in biomedical and pharmaceutical sciences.

Palabras Clave

Catanionic VesiclesDrug CarrierAmphiphilic Cyclodextrin

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http://hdl.handle.net/11336/92256