Microwave-assisted conditions for the green synthesis of thioacetamide. Optimization of reaction parameters using response surface methodology

Artículo

Autoría

Dominguez, Rodrigo Ezequiel ; PFAFFEN, MARIA VALERIA DEL VALLE ; Argüello, Gustavo Alejandro ; IRIARTE, ANA GRACIELA

Fecha

2018

Editorial y Lugar de Edición

Elsevier B.V.

Revista

Sustainable Chemistry and Pharmacy, vol. 9 (pp. 51-62) - ISSN 2352-5541
Elsevier B.V.

ISSN

2352-5541

Resumen Información suministrada por el agente en SIGEVA

An optimized method for the synthesis of thioacetamide (TA) in relation to the consumption of materials and energy, which reduces the production of waste and minimizes costs, is hitherto presented. The most important highlight of this work is the use of an inexpensive and readily accessible reactant for the thionation process (i.e. phosphorus pentasulfide, P4S10), combined with both alumina as solid support and a non-conventional microwave (MW) irradiation technique. In addition to this, Respon... An optimized method for the synthesis of thioacetamide (TA) in relation to the consumption of materials and energy, which reduces the production of waste and minimizes costs, is hitherto presented. The most important highlight of this work is the use of an inexpensive and readily accessible reactant for the thionation process (i.e. phosphorus pentasulfide, P4S10), combined with both alumina as solid support and a non-conventional microwave (MW) irradiation technique. In addition to this, Response Surface Methodology (RSM) was used to optimize the entire procedure of the synthesis for simultaneous tripled-maximization of Yield (?), Mass Intensity (MI) and Mass Productivity (MP). Acetamide (AC)/P4S10 molar ratio, time and temperature of reaction were chosen as independent variables; while ? MI and MP were chosen as responses. The determination of these green metrics parameters allow to evaluate the sustainability of the reaction and compare with other methodologies. A quadratic regression model was derived with satisfactory prediction. Tripled optimization with desirability function predicts a maximum ? of 100%, maximum MI of 29.00 kg/kg and a maximum MP of 3.45% under the following experimental conditions: AC/P4S10 molar ratio of 2.10, time of irradiation of 14 min and a temperature 140 °C.

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Palabras Clave

THIOACETAMIDERSM FACTORIAL DESIGNMICROWAVE-ASSISTED SYNTHESISTHIONATION

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http://hdl.handle.net/11336/90790