Producción CyT
Artículo
Autoría
Clément, Florencia
;
MARTIN, AYELEN
;
Venara, Marcela Cristina
;
Calcagno, Maria de Luján
;
Mathó Pacielo, Cecilia
;
Maglio, Silvana
;
Garcia Lombardi, Mercedes
;
BERGADÁ, IGNACIO
;
PENNISI, PATRICIA ALEJANDRA
Fecha
2018
Editorial y Lugar de Edición
Springer
Revista
Hormones and Cancer,
vol. 9
(pp. 205-214)
- ISSN 1868-8497
Springer
Springer
ISSN
1868-8497
Resumen
Información suministrada por el agente en
SIGEVA
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were ch...
Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were characterized by immunohistochemistry (IHC), subcellular fractionation and western blotting. Tumours (47/53) showed positive staining for IGF-1R by IHC. IGF-1R nuclear labelling was observed in 10/47 cases. IGF-1R staining was mostly non-nuclear in low-grade tumours, while IGF-1R nuclear labelling was predominant in high-grade gliomas (p = 0.0001). Survival was significantly longer in patients with gliomas having non-nuclear IGF-1R localization than in patients with nuclear IGF-1R tumours (p = 0.016). In gliomas, IGF-1R nuclear localization was significantly associated with both high-grade tumours and increased risk of death. Based on a prospective design, we provide evidence of a potential usefulness of intracellular localization of IGF-1R as prognostic factor in paediatric patients with gliomas.
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Palabras Clave
nuclear IGF-1RIGF-1Rpediatric gliomaglioblastoma
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