Producción CyT
Congreso
Autoría
Justo ME
;
Aldecoa M
;
Aguirre F
;
Cela EM
;
Villa A
;
Leoni J
;
González Maglio DH
;
PAZ, MARIELA LAURA
Fecha
2019
Editorial y Lugar de Edición
Estudio Sigma SRL
Resumen
Información suministrada por el agente en
SIGEVA
Myasthenia Gravis (MG) is an autoimmune disease mediated by anti-acetylcholine receptor autoantibodies (ACRA) mainly, whose production is T cell dependent and controlled by regulatory T lymphocytes (Tregs), which are diminished in MG patients. Vitamin D (VitD) has immunomodulatory effects, stimulating Tregs and inhibiting effector T cells. A controversial association between VitD deficiency and MG development and severity has been established. We compared 25-OH-VitD serum levels in 66 diagnosed...
Myasthenia Gravis (MG) is an autoimmune disease mediated by anti-acetylcholine receptor autoantibodies (ACRA) mainly, whose production is T cell dependent and controlled by regulatory T lymphocytes (Tregs), which are diminished in MG patients. Vitamin D (VitD) has immunomodulatory effects, stimulating Tregs and inhibiting effector T cells. A controversial association between VitD deficiency and MG development and severity has been established. We compared 25-OH-VitD serum levels in 66 diagnosed MG patients and 25 healthy volunteers (hv) and related them with the severity of the disease and other biomarkers, in an Argentinian cohort. We collected samples equally distributed through the year and balanced according to sunlight exposure and VitD intake through a validated questionnaire. We measured: 25-OH-VitD (chemiluminescence), C3 and C4 (RID), C5a (ELISA) and ACRA (RIA).There were no statistically significant (ss) differences in 25-OH-VitD mean serum levels between patients and hv, neither between basal and exacerbated patients. Deficient levels of 25-OH-VitD (<25 ng/ml) were found in 76,9% of MG patients vs. 56% of hv (p=0,046). We found a tendency (p=0,068) when analyzing 25-OH-VitD mean serum levels of the individuals that met the VitD Reference Daily Intake (RDI: 5µg/day): patients (19,5ng/mL) and hv (24,6ng/mL). We were not able to find general differences between VitD levels in MG patients and hv in our total population. However, patients and hv that met the RDI, showed different 25-OH-VitD levels. We found an association between 25-OH-VitD deficiency and illness, though no correlation with the severity of MG or other biomarkers could be established.
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Palabras Clave
DEFICIENCYSUNLIGHT EXPOSUREMYASTHENIA GRAVISVITAMIN DBIOMARKERS