Producción CyT
Artículo
Autoría
Cela EM
;
González C
;
Friedrich AD
;
Ledo C
;
PAZ, MARIELA LAURA
;
Leoni J
;
Gomez M
;
González Maglio DH
Fecha
2018
Editorial y Lugar de Edición
WILEY-BLACKWELL PUBLISHING, INC
Revista
IMMUNOLOGY,
vol. 154
(pp. 510-521)
WILEY-BLACKWELL PUBLISHING, INC
Resumen
Información suministrada por el agente en
SIGEVA
Ultraviolet radiation (UVr) promotes several well-known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand, UVr also promotes Vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of UVr on four consecutive days (repetitive low UVd or rlUVd) does not promote an inflammatory state, nor the recruitment of neutrophils or lymph...
Ultraviolet radiation (UVr) promotes several well-known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand, UVr also promotes Vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of UVr on four consecutive days (repetitive low UVd or rlUVd) does not promote an inflammatory state, nor the recruitment of neutrophils or lymphocytes, as the exposure to a single high UV dose (shUVd) does. Moreover, rlUVd reinforce the epithelium by increasing antimicrobial peptides transcription and epidermal thickness. The aim of this study was to evaluate the adaptive immune response after shUVd and rlUVd, determining T and B cell responses. Finally, we challenged animals exposed to both irradiation procedures with Staphylococcus aureus to study the overall effects of both innate and adaptive immunity during a cutaneous infection. We observed, as expected, a marked suppression of T and B cell responses after exposure to a shUVd but a novel and significant increase in both specific responses after exposure to rlUVd. However, the control of the cutaneous S. aureus infection was defective in this last group, suggesting that responses against pathogens cannot be ruled out from isolated stimuli.
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Palabras Clave
SKINULTRAVIOLET RADIATIONIMMUNOSUPPRESSIONIMMUNOSTIMULATIONBACTERIAL INFECTION