Producción CyT
Artículo
Autoría
Alejandro Ferrari
;
Federico S. Weill
;
PAZ, MARIELA LAURA
;
Juliana Leoni
Fecha
2005
Editorial y Lugar de Edición
MEDICINA (BUENOS AIRES)
Revista
MEDICINA (BUENOS AIRES),
vol. 65
(pp. 103-107)
MEDICINA (BUENOS AIRES)
Resumen
Información suministrada por el agente en
SIGEVA
A classical paradigm in immunology establishes that for the isotype switch to take place in antibodies, it is a sine qua non condition that the antigen is presented by an antigen presenting cell to a helper T cell. In the present study an animal model of the immune response against two typical antigens was designed in BALB/c mice. Dextran was chosen as a T independent antigen (TIAg), and bovine seroalbumin (BSA) as a T dependant antigen (TDAg), and the response was studied, analyzing the isotyp...
A classical paradigm in immunology establishes that for the isotype switch to take place in antibodies, it is a sine qua non condition that the antigen is presented by an antigen presenting cell to a helper T cell. In the present study an animal model of the immune response against two typical antigens was designed in BALB/c mice. Dextran was chosen as a T independent antigen (TIAg), and bovine seroalbumin (BSA) as a T dependant antigen (TDAg), and the response was studied, analyzing the isotypes of the specific antibodies produced. The results show that the response against dextran, in the presence of BSA, takes place with isotype switch, essentially from IgM to IgG1. These experiments suggest that BSA generates a switch inductor biochemical environment in its own processing pathway as well as in the dextran's. These results indicate that the exclusive association of TDAgs with isotype switch responses is inaccurate. Considering the proposed model, it seems unlikely the finding of a spontaneous in vivo case in which TIAgs enter the organism isolated; instead, it is much more probable that they would enter together with TDAgs, and in consequence the isotype switch would take place.
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Palabras Clave
RESPUESTA INMUNEANTIGENOS T INDEPENDIENTESDEXTRANCAMBIO DE ISOTIPOSEROALBUMINA BOVINA