Producción CyT

ANGIOGENESIS AT DIFFERENT STAGE OF PREGNANCY IN GOAT PLACENTA

Articulo

Autoría:

DIAZ, TOMAS ; MERKIS, CECILIA ; COTS, DEBORA ; SANCHIS, EVA GABRIELA ; CRISTOFOLINI, ANDREA LORENA ; ROMANINI, MARÍA CRISTINA ; BOZZO, ANDREA ; ROLANDO, ALICIA

Fecha:

2015

Editorial y Lugar de Edición:

ROYAL NETHERLANDS SOC AGR SCI

Revista:

NJAS-WAGENINGEN JOURNAL OF LIFE SCIENCES, vol. 9 (pp. 391-398) ROYAL NETHERLANDS SOC AGR SCI

Resumen *

Abstract: The increase intransplacental exchange depends primarily on the great development of the placental vascular bed. The aimof this study was to evaluate the pattern of placental vascular development at day 50 and 100 of pregnancy in goats and therelationship with the vascular endothelial growth factor (VEGF) immunolocalization. The placental morphometric variables:capillary area density, capillary perimeter density, capillary number density and average capillary perimeter of the caruncular (CAR)and cotyledonary (COT) tissues were measured at day 50 (n = 5) and 100 (n = 5) of gestation. Also, the immunolocalization ofVEGF was performed. In the CAR and COT tissues a significant increase of capillary area density and capillary perimeter density atday 100 of the gestation was observed. In the COT tissue, this was due to the increase in the capillary number density; however in theCAR tissue this was due to the increase in the capillary size. We can conclude that in both tissues there were different strategies toincrease the capillary area and, thereby, the nutrients exchange. The immunolocalization of VEGF in the COT tissue showed theendothelial cells of blood vessels and trophoblastcells surrounding the villi intensely inmunostained, which would indicate theinvolvement of VEGF in the placental vascular development. Información suministrada por el agente en SIGEVA