Producción CyT
Congreso
Autoría
Fecha
2011
Editorial y Lugar de Edición
Inca Editorial
ISSN
0327-9545
Resumen
Información suministrada por el agente en
SIGEVA
The aim of this study was to determine the effects of Sildenafil and L-NAME on fetal growth and placental efficiency in mice. Pregnant Balb/c mice were used (n=16) and divided into 3 groups: 1) control, 2) L-NAME (50 mg / kg) applied on day 6 of pregnancy and 3) Sildenafil (10 mg / kg) administered on day 7 of pregnancy. The animals were euthanized on day 17 of pregnancy. Embryonic vesicles were counted in each female. In right horn uterine fetuses were measured and weighed with its correspondi...
The aim of this study was to determine the effects of Sildenafil and L-NAME on fetal growth and placental efficiency in mice. Pregnant Balb/c mice were used (n=16) and divided into 3 groups: 1) control, 2) L-NAME (50 mg / kg) applied on day 6 of pregnancy and 3) Sildenafil (10 mg / kg) administered on day 7 of pregnancy. The animals were euthanized on day 17 of pregnancy. Embryonic vesicles were counted in each female. In right horn uterine fetuses were measured and weighed with its corresponding placenta. Fetal weights in the L-NAME group were significantly reduced compared to control group (p = 0.0398) but did not alter placental efficiency. No significant differences were observed in fetal and placental weight, and placental efficiency in Sildenafil group. In conclusion, L-NAME could be used as a model of intrauterine growth restriction. The placental efficiency and growth restriction are not affected by Sildenafil in normal female mice.
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Palabras Clave
PLACENTAL EFFICIENCYSILDENAFIL