Producción CyT
Artículo
Autoría
Pasqualone, Magalí
;
OBERTI, TAMARA GISELA
;
Andreetta, Héctor Alfredo
;
Cortizo, Maria Susana
Fecha
2013
Editorial y Lugar de Edición
Springer
Revista
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,
vol. 24
(pp. 1683-1692)
Springer
Resumen
Información suministrada por el agente en
SIGEVA
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kin...
Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.
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Palabras Clave
MEMBRANA TRANSDERMICASLIBERACION CONTROLADACOPOLIMEROS
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