Producción CyT
BIOCELL - PLATELET SEROTONIN IN ALCOHOLIC PATIENTS, IN RELATION TO EFFICIENCY OF CLOMETIAZOL. CART EFFECTS.
Congreso
Autoría:
Llinas Carrillo S ; Leytes E ; Abud M ; Ponce C ; Cejudo C ; Cayado Gutiérrez N ; Bianchi RAFecha:
2009Editorial y Lugar de Edición:
Inca EditorialISSN:
0327-9545Resumen *
The relation of serotonine and alcoholism is a recognized fact in the international literature. The relation between the serotoninergic neurotransmision and the Alcohol Abstinence Syndrome (AAS) shows some experimental published results. In the present work there is valued the effect of two tranquilizing medicaments for the AAS: clometiazol and clordiazepoxid and its relation with the levels of plateret serotonin and serotonin captures. A clinical test was realized Phase III randomized. Criteria diagnosis and selection from the Manual of diagnosis and statistics DSM IV are used, as well as scales of global clinical impressions and of the AAS. The clinical test included fifty male patients, aged average from 35 to 45, in which samples of blood were obtained trough Venous puncture(10 ml) in order to obtain enriched platelet plasma. These tests were realized at the first and tenth day of treatment. The efficiency of clometiazol on the serotonin functioning in the treatment of AAS were evaluated, as well as comparisons with the effect of clometiazol on the capture of platelets serotonine. Serotonine capture and platelet serotonine values showed statistically significant results (p <0,005 and p <0,001) respectively between first and last day of study. In addition, analysis of what happened was realized when serotonin capture and the serotonin were compared. There were no diferences between pharmacological effects of both medicaments. In the preliminary results can be inferred that those patients with low punctuations in abstinence scale present major platelet concentration of seotonina and captation. Peliminary test results of CART peptides showed an increased level in relation to serotonin obtained values. Información suministrada por el agente en SIGEVAPalabras Clave
ALCOHOL ABSTINENCE SYNDROME