Producción CyT

BIOCELL - BRAIN BIOENERGETICS AND COGNITIVE PERFORMANCE IN A TRANSGENIC RAT MODEL OF EARLY ALZHEIMER'S DISEASE

Congreso

Autoría:

Martino Adami P ; Quijano C ; Magnani, N ; Galeano, P. ; Cassina A ; Leal Maria C. ; Cuello C ; MORELLI, LAURA

Fecha:

2015

Editorial y Lugar de Edición:

Zeta Editores

Resumen *

Synaptic bioenergetic deficiencies may be associated with early Alzheimer's disease (AD). To explore this concept we assessed pre-synaptic mitochondrial function in hemizygous (+/-) TgMcGill-R-Thy1-APP rats. The low burden of Aβ and the wide array of behavioral and cognitive impairments described in 6 month-old hemizygous TgMcGill-RThy1-APP rats (Tg(+/-)) support their use to investigate synaptic bioenergetics deficiencies described in subjects with early AD. Here we show that pre-synaptic mitochondria from Tg(+/-) rats evidence a decreased respiratory control ratio and spare respiratory capacity associated with deficits in complex I enzymatic activity. Cognitive impairment was prevented and bioenergetic deficits partially reversed when Tg(+/-) rats were fed a nutritionally complete diet from weaning to 6 month-old supplemented with pyrroloquinoline quinone, a mitochondrial biogenesis stimulator with antioxidant and neuroprotective effects. These results provide evidence that, as described in AD brain and not proven in Tg mice models with AD-like phenotype, the mitochondrial bioenergetic capacity of synaptosomes is not conserved in the Tg(+/-) rats. This animal model may be suitable for understanding the basic biochemical mechanisms involved in early AD. Información suministrada por el agente en SIGEVA

Palabras Clave

Synaptic bioenergetic behavioral testsTransgenic ratsMitochondrial function