Producción CyT
Artículo
Autoría
Cerliani Juan Pablo
;
Vanzulli Silvia I.
;
PEREZ PIÑERO, CECILIA
;
Bottino María C
;
Sahores Ana
;
Nuñez Myriam
;
Varchetta Romina
;
Martins Rubén
;
Zeitlin Eduardo
;
Hewitt Stephen M.
;
Molinolo Alfedro A.
;
Lanari Claudia
;
Lamb Caroline
Fecha
2011
Editorial y Lugar de Edición
SPRINGER
Revista
BREAST CANCER RESEARCH AND TREATMENT,
vol. 133
(pp. 997-1008)
SPRINGER
Resumen
Información suministrada por el agente en
SIGEVA
Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors which have been implicated in breast cancer. The aim of this study was to evaluate FGFR-1, -2, -3, and -4 protein expressions in normal murine mammary gland development, and in murine and human breast carcinomas. Using immunohistochemistry and Western blot, we report a hormonal regulation of FGFR during postnatal mammary gland development. Progestin treatment of adult virgin mammary glands resulted in changes in localizati...
Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors which have been implicated in breast cancer. The aim of this study was to evaluate FGFR-1, -2, -3, and -4 protein expressions in normal murine mammary gland development, and in murine and human breast carcinomas. Using immunohistochemistry and Western blot, we report a hormonal regulation of FGFR during postnatal mammary gland development. Progestin treatment of adult virgin mammary glands resulted in changes in localization of FGFR-3 from the cytoplasm to the nucleus, while treatment with 17-β-estradiol induced changes in the expressions and/or localizations of FGFR-2 and -3. In murine mammary carcinomas showing different degrees of hormone dependence, we found progestin-induced increased expressions, mainly of FGFR-2 and -3. These receptors were constitutively activated in hormone-independent variants. We studied three luminal human breast cancer cell lines growing as xenografts, which particularly expressed FGFR-2 and -3, suggesting a correlation between hormonal status and FGFR expression. Most importantly, in breast cancer samples from 58 patients, we found a strong association (P < 0.01; Spearman correlation) between FGFR-2 and -3 expressions and a weaker correlation of each receptor with estrogen receptor expression. FGFR-4 correlated with c-erbB2 over expression. We conclude that FGFR-2 and -3 may be mechanistically linked and can be potential targets for treatment of estrogen receptor-positive breast cancer patients.
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Palabras Clave
Mammary carcinomasFibroblast growth factor receptorsBreast cancerMammary glands