Producción CyT
Congreso
Autoría
Senovieski, Matías Luis *igual contribución
;
Villaba, Sofía *igual contribución
;
MARTIN, AYELEN
;
Bisagno, Verónica
;
Pennisi, Patricia
Fecha
2025
Editorial y Lugar de Edición
Fundación Revista Medicina
Resumen
Información suministrada por el agente en
SIGEVA
Noribogaine is the main active metabolite of ibogaine, a psychedelic drug that targets the serotonin 2A receptor (5-HT2A). This receptor has been linked to the pro-inflammatory effects of serotonin, and its expression has been particularly detected in astrocytes and microglia. The human glioblastoma cell line U87MG expresses receptors for various neurotransmitters, including the serotonin receptor, which is associated with cell proliferation, migration, and survival.The aim of this study was to...
Noribogaine is the main active metabolite of ibogaine, a psychedelic drug that targets the serotonin 2A receptor (5-HT2A). This receptor has been linked to the pro-inflammatory effects of serotonin, and its expression has been particularly detected in astrocytes and microglia. The human glioblastoma cell line U87MG expresses receptors for various neurotransmitters, including the serotonin receptor, which is associated with cell proliferation, migration, and survival.The aim of this study was to investigate the effect of noribogaine as an inhibitor of U87MG cell viability and its potential role in modulating the immune response of glioma cells. U87MG cell viability was analyzed in the presence of different concentrations of noribogaine (0.1 to 100 µM), with cell counts performed at 24 and 72 hours. A decrease in U87MG cell viability was observed at noribogaine concentrations of 50 and 100 µM (Kruskal–Wallis test, p < 0.05).To evaluate changes in the expression of pro- and anti-inflammatory genes (IL1β, TNFα, and TGFβ) by qPCR, concentrations of 10 µM (no effect on cell viability) and 50 µM (lowest concentration with a significant effect) were selected for 1- and 72-hour cultures. Results showed changes in the expression profiles of pro- and anti-inflammatory genes under both acute and chronic noribogaine stimulation.In conclusion, the presence of noribogaine decreases the viability of U87MG cells and may modulate their immune response profile.
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Palabras Clave
NoribogaineGlioblastoma