Producción CyT
Congreso
Autoría
Fecha
2022
Editorial y Lugar de Edición
SAB
ISSN
0327-9545
Resumen
Información suministrada por el agente en
SIGEVA
The perinatal environment is important for the neurophysiological and behavioral development of offspring. There is evidence that bothpositive stimuli such as maternal Environmental Enrichment (EE) and negative stimuli such as exposure to postnatal stressors generateneurostructural and behavioral changes in rodents. On the other hand, the brain is a sexually dimorphic structure and differential effectsof EE on neuroendocrine and behavioral responses in animals have been described. In this work,...
The perinatal environment is important for the neurophysiological and behavioral development of offspring. There is evidence that bothpositive stimuli such as maternal Environmental Enrichment (EE) and negative stimuli such as exposure to postnatal stressors generateneurostructural and behavioral changes in rodents. On the other hand, the brain is a sexually dimorphic structure and differential effectsof EE on neuroendocrine and behavioral responses in animals have been described. In this work, we analyzed whether gestational EEcould influence social and emotional behavior in male and female adolescent rats and whether it could modulate behavioral responsesto early-life stress. Two-month-old virgin Wistar rats were mated and then housed during gestation (from day 1 to day 20) in EE cages(larger size, toys, running wheels, tunnels, ramps, etc.) in groups of 8 pregnant females or in standard cages in groups of 2. On postnataldays (PND) 1 to 21, one of the following stress conditions was applied: the presence of intruder male (IM), maternal separation (MS),or no stress. After weaning at PND 21, the offspring were separated by sex in standard cages. Between PND 45?50 offspring wereassessed in Open Field (OF), Elevated Plus Maze (EPM), and Social Preference (SP). It was observed that females, regardless ofgestational or postnatal condition, present a higher number of line-crosses and rearings, and spend more time in the center of the OF andin the open arms of the EPM compared to males. Nevertheless, males have a higher SP index. Interestingly, in animals subjected to earlystress, an increase in the number of line-crossings, number of entries to the center, and a higher SP index were observed. On the otherhand, the offspring of EE mothers presented a higher number of entries and time spent in open arms and a higher SP index. These resultssuggest that perinatal stimuli have differential effects on the behavior of adolescent male and female rats; females show fewer anxietylike and social behaviors, but more exploratory behaviors than males. In turn, gestational EE prevents some of the deleterious effects ofearly exposure to stress. These results indicate that gestational EE may be a promising strategy for the future well-being of adolescents.
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Palabras Clave
ENRIQUECIMIENTO GESTACIONALESTRESCOMPORTAMIENTO