Producción CyT
Treatment of Indolent Ulcer with cultured canine mesenchymal stem cells
Artículo
Fecha:
2025Editorial y Lugar de Edición:
AJMCRRRevista:
American Journal of Medical and Clinical Research & Reviews, vol. 03 (pp. 1-6) AJMCRRResumen *
Background: Indolent ulcers are noninfectious epithelial defects of the cornea, typically presenting as chronic, superficial lesions. These ulcers are most commonly observed in dogs and are the leading cause of ophthalmic consultation in the UVS Ophthalmology service. These ulcers, which are more common in older dogs, often have difficulty healing naturally. Underlying eye conditions and infections can further hinder the healing process, potentially causing vision impairment and eventually removal of the eye.In this manuscript, we present the success of using mesenchymal stem cells (MSC) in a prelimi-nary pilot trial to treat indolent ulcers. Methods: Companion animals with indolent eye ulcers that did not respond to traditional treatment protocols were treated with suspended canine bone marrow-derived MSCs (5 x 105cells total) adminis-tered via an eyedropper and then monitored for a period of 2-3 hours post infusion before being re-leased back to their owners. Dogs had a follow up visit after 48-72 hours by the veterinary team. Results:Of the 12adult canine pets with indolent ulcers, MSC treatment led to recovery of the ulcers within 5-6 weeks after administration. Información suministrada por el agente en SIGEVAPalabras Clave
MSCINDOLENTSTEM cELLSDOG