Producción CyT
Artículo
Autoría
Longarzo, Mria Lucrecia
;
VAZQUEZ, ROMINA FLORENCIA
;
BELLINI, MARIA JOSE
;
Zamora, Ricardo A.
;
Redondo Morata, Lorena
;
Giannotti, Marina I.
;
Oliveira, Osvaldo N.
;
FANANI, MARIA LAURA
;
MATE, SABINA MARIA
Fecha
2024
Editorial y Lugar de Edición
Elsevier Inc.
Revista
iScience,
vol. 27
(pp. 1-16)
- ISSN 2589-0042
Elsevier Inc.
Elsevier Inc.
ISSN
2589-0042
Resumen
Información suministrada por el agente en
SIGEVA
A deficiency in omega-3 fatty acids (?3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided ?3 FAs as a supplement to spontaneously hypertensive rats (SHR+ ?3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in ?3 levels in the cerebral cortex of SHR+ ?3 were observed, leading to alterations in brain lipid m...
A deficiency in omega-3 fatty acids (?3 FAs) in the brain has been correlated with cognitive impairment, learning deficiencies, and behavioral changes. In this study, we provided ?3 FAs as a supplement to spontaneously hypertensive rats (SHR+ ?3). Our focus was on examining the impact of dietary supplementation on the physicochemical properties of the brain-cell membranes. Significant increases in ?3 levels in the cerebral cortex of SHR+ ?3 were observed, leading to alterations in brain lipid membranes molecular packing, elasticity, and lipid miscibility, resulting in an augmented phase disparity. Results from synthetic lipid mixtures confirmed the disordering effect introduced by ?3 lipids, showing its consequences on the hydration levels of the monolayers and the organization of the membrane domains. These findings suggest that dietary ?3 FAs influence the organization of brain membranes, providing insight into a potential mechanism for the broad effects of dietary fat on brain health and disease.
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Palabras Clave
MODEL MEMBRANESDHA-CEREBRAL CORTEXOMEGA-3 FATTY ACIDSPHYSICOCHEMICAL PROPERTIES
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