Producción CyT
Biocell - CHEMICAL ANALYSIS, BIOLOGICAL IN VITRO AND IN VIVO PROPERTIES AND BEHAVIORAL EFECTS OF Oxalis erythrorhiza GILLIES EX HOOKER ET ARNOTT (OXALIDACEAE)
Congreso
Autoría:
Gomez, J. ; Rey, M. ; Kruse, M.S ; Gamarra-Luques, C. ; Zaragoza, J. ; Lima, B. ; Simirgiotis, M.J. ; COIRINI, HECTOR ; Tapia, A.Fecha:
2025Editorial y Lugar de Edición:
IncaResumen *
Oxalis erythrorhizaGillies ex Hooker et Arnott (Oxalidaceae), native to the central Andean regionof Argentina, is consumed to treat health disorders, despite the lack of scientificsupport. In this work, a decoction (10%W/V, DOe) and a methanolic globalextract (MGEOe) from its aerial parts were studied. The metabolite profiling wasdetermined with ultrahigh resolution liquid chromatography orbitrap MS analysis(UHPLC-ESI-OT-MS) and ultra-high-resolution liquid chromatography coupled withelectrospray ionization quadrupole time-of-flight mass spectrometry(UHPLC-ESI-QTOF-MS), revealing thirty-eight compounds that includes flavone,isoflavones, fatty acids, terpenes, phenolic acids, and sterols. The antioxidantproperties were assessed through 2,2-diphenyl-1-picrylhydrazyl (DPPH), troloxequivalent antioxidant activity (TEAC), ferric-reducing antioxidant power(FRAP), and inhibition of lipid peroxidation in erythrocytes (ILP) assays, demonstratingstrong antioxidant activities. The cytotoxic effects were tested in HCT-116 tumoralcell line, showing selective actions. DOe was evaluated in an animal model ofinsulin-resistance. Male SD rats received sucrose (10%W/V, S), a half dilutionof DOe (5%W/V) with sucrose (HDOeS) or DOe with sucrose (DOeS) from PND21 toPND61. After this, the anxiety-like behavior and spatial memory were assessedusing the open field (OF) and the novel object location (NOL) tests,respectively. Serum parameters glycemia (G), total cholesterol (C) andtryglicerides (T) were measured using commercial kits. Only HDOeS exhibitedlower anxiety-like behavior in OF and improved performance in NOL compared toS. Furthermore, DOeS showed reduced serum parameters, while HDOeS presented lowerC levels than S. The beneficial properties of these preparations could beattributed to the identified metabolites. Although further studies are neededto elucidate the precise mechanisms underlying these actions, the present resultshighlight O. erythrorhiza as apromising source of compounds applicable in health. (PICT2019-623). Información suministrada por el agente en SIGEVAPalabras Clave
CYTOTOXIC EFFECTUHPLC-ESI-OT-MSOXALIS ERYTHRORHIZAANXIETY