Producción CyT
Multi-responsive nanogels for the selective delivery of antimicrobial drugs to mucosal tissues
Artículo
Fecha:
2024Editorial y Lugar de Edición:
AMER CHEMICAL SOCRevista:
BIOMACROMOLECULES, vol. 25 (pp. 5968-5978) AMER CHEMICAL SOCResumen *
Effective drug delivery to the bacterially infected mucosa remains a challenge due to the barrier function of mucus combined with local variations in pH and high concentrations of glutathione. However, polysaccharide-based responsive nanogels (NGs) can take advantage of these conditions to specifically deliver antimicrobial drugs. We explored the critical features of pH- and redox-responsive NGs to increase drug penetration, residence time, and therapeutic efficacy in infected mucosa. We prepared multifunctional NGs using hydroxypropyl cellulose (HPC) as a template for the crosslinking of methacrylic acid (MAA) with N,N′-bis(acryloyl)cystamine (BAC) or N,N´-methylenebis(acrylamide) (BIS). Studies of NG-mucin binding and the anti-bacterial efficacy of doxycycline-loaded NGs revealed the interplay between the response to pH and redox clues. Specifically, higher BAC composition increased mucus binding and controlled release in reductive conditions, while higher BIS composition yielded NGs with higher doxycycline-mediated anti-bacterial efficacy against Staphylococcus aureus. The findings reveal the potential of multi-responsive NGs in the delivery and activity of antimicrobials in the context of infected mucosa. Información suministrada por el agente en SIGEVAPalabras Clave
HYDROXIPROPYLCELLULOSEMUCOSAL INTERACTIONpH RESPONSIVINESSANTIMICROBIAL ACTIVITY