Producción CyT
Aquaporin 2 in the early stages of the adenine-induced chronic kidney diasease model
Articulo
Autoría:
Oronel, L ; Ortiz, MC ; Yarza, C ; Gayone, S ; Davio, C ; Majowicz, MP ; ALBERTONI BORGHESE, MARIA FLORENCIAFecha:
2025Editorial y Lugar de Edición:
PUBLIC LIBRARY SCIENCERevista:
PLOS ONE PUBLIC LIBRARY SCIENCEResumen *
Chronic kidney disease (CKD) is one of the leading health problems in the world. It is silent in the early stages and gradually progresses, inducing renal physiological and structural alterations. Moreover, CKD is associated with impaired life quality, increased risk for cardiovascular diseases, and reduced life expectancy. Different CKD models differ in underlying etiology, time of onset, and associated diseases. The 0.25% adenine diet induces progressive kidney damage, constituting an adequate model mimicking human CKD. Vasopressin (VP) was postulated as a mediator of CKD, mainly acting through its V2 receptors. However, the molecular mechanisms involved in the pathogenesis of this condition and its progression still are not entirely understood. This study aimed to evaluate if AQP2 expression is altered in an adenine-induced model of CKD in rats at early stages of development (two weeks) and to assess a potential beneficial effect of Tolvaptan treatment. We showed an increased renal medullary AQP2 expression at two weeks of adenine administration. This increase was mainly cytoplasmic, explaining the increased urinary volume of CKD rats and suggesting a possible non-canonical role for AQP2. In addition, Tolvaptan effectively inhibited the V2 receptor in both control and CKD rats, decreasing AQP2 expression and increasing diuresis. Moreover, Tolvaptan slightly reduced BUN and plasma creatinine. On the other hand, the renal alterations induced by adenine in CKD rats were not prevented by Tolvaptan. Información suministrada por el agente en SIGEVAPalabras Clave
ADENINECHRONIC KIDNEY DISEASEAQUAPORIN 2