Producción CyT
Artículo
Autoría
Torres, Carolina
;
Nabaes Jodar, Mercedes
;
Acuña, Dolores
;
Montaño, Romina Micaela Zambrana
;
Culasso, Andrés Carlos Alberto
;
Amadio, Ariel Fernando
;
Aulicino, Paula
;
Ceballos, Santiago
;
Cacciabue, Marco
;
Debat, Humberto
;
Dus Santos, María José
;
Eberhardt, María Florencia
;
Espul, Carlos
;
Fay, Fabián
;
Fernández, María Ailén
;
Fernández, Franco
;
Muñoz, Juan Manuel Fernandez
;
Ferrini, Florencia
;
Gallego, Fernando
;
Giri, Adriana Angélica
;
Cerri, Agustina
;
Bolatti, Elisa
;
Gismondi, María Ines
;
Goya, Stephanie
;
Gramundi, Iván
;
Irazoqui, José Matías
;
König, Guido Alberto
;
Leiva, Viviana
;
Lucero, Horacio
;
Marquez, Nathalie
;
Nardi, Cristina
;
Ortiz, Belén
;
Pianciola, Luis
;
Pintos, Carolina Beatriz
;
Puebla, Andrea Fabiana
;
Rastellini, Carolina Victoria
;
Rojas, Alejandro Ezequiel
;
Sfalcin, Javier
;
Suárez, Ariel
;
Tittarelli, Estefanía
;
Toro, Rosana
;
Villanova, Gabriela Vanina
;
Ziehm, María Cecilia
;
Zimmermann, María Carla
;
Zunino, Sebastián
;
Valinotto, Laura
;
Viegas, Mariana
Fecha
2023
Editorial y Lugar de Edición
MDPI
Revista
Viruses,
vol. 15
(pp. 1-13)
- ISSN 1999-4915
MDPI
MDPI
ISSN
1999-4915
Resumen
Información suministrada por el agente en
SIGEVA
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed. A differential dynamic between the Omicron waves was found. The third wave was associated with lineage BA.1, characterized by a high number of c...
The COVID-19 pandemic has lately been driven by Omicron. This work aimed to study the dynamics of SARS-CoV-2 Omicron lineages during the third and fourth waves of COVID-19 in Argentina. Molecular surveillance was performed on 3431 samples from Argentina, between EW44/2021 and EW31/2022. Sequencing, phylogenetic and phylodynamic analyses were performed. A differential dynamic between the Omicron waves was found. The third wave was associated with lineage BA.1, characterized by a high number of cases, very fast displacement of Delta, doubling times of 3.3 days and a low level of lineage diversity and clustering. In contrast, the fourth wave was longer but associated with a lower number of cases, initially caused by BA.2, and later by BA.4/BA.5, with doubling times of about 10 days. Several BA.2 and BA.4/BA.5 sublineages and introductions were detected, although very few clusters with a constrained geographical distribution were observed, suggesting limited transmission chains. The differential dynamic could be due to waning immunity and an increase in population gatherings in the BA.1 wave, and a boosted population (for vaccination or recent prior immunity for BA.1 infection) in the wave caused by BA2/BA.4/BA.5, which may have limited the establishment of the new lineages.
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Palabras Clave
BA.2EVOLUTIONVARIANTSBA.5SARS-COV-2BA.1DYNAMICSSOUTH AMERICABA.4OMICRONBA.5SARS-COV-2BA.2EVOLUTIONVARIANTSBA.4OMICRONBA.1DYNAMICSSOUTH AMERICA