Producción CyT
Artículo
Autoría
Aguirre, Florencia
;
Manin, Analisa
;
Fernandez, Victoria C.
;
Justo, Mariano Ezequiel
;
Leoni, Juliana
;
PAZ, MARIELA LAURA
;
Villa, Andres Maria
Fecha
2020
Editorial y Lugar de Edición
SAGE Publications Ltd
Revista
Therapeutic Advances in Neurological Disorders,
vol. 13
(pp. 1-8)
- ISSN 1756-2856
SAGE Publications Ltd
SAGE Publications Ltd
ISSN
1756-2856
Resumen
Información suministrada por el agente en
SIGEVA
Background: Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as potential severity biomarkers in MG. Methods: Levels of C3, C4, C5a, and AChR-ab were measured in 60 AChR-ab-positive patients with MG. Their relationship with clinical severity was analyzed using the activities of daily living (ADL) and MG composite ...
Background: Although the pathogenesis of myasthenia gravis (MG) is well known, prognostic markers are not yet available. We assessed the utility of anti-acetylcholine receptor (AChR) antibody (AChR-ab) titer and concentration of C3, C4, and C5a as potential severity biomarkers in MG. Methods: Levels of C3, C4, C5a, and AChR-ab were measured in 60 AChR-ab-positive patients with MG. Their relationship with clinical severity was analyzed using the activities of daily living (ADL) and MG composite (MGC) scales. Results: AChR-ab titer correlated with severity of MG according to ADL (p = 0.002) and MGC scales (p = 0.001). When patients were classified according to disease duration, a statistically significant correlation between AChR-ab titer and clinical severity was only found in the subgroup of patients with fewer than 5 years from symptoms onset. C5a levels showed a positive correlation with MG severity according to the ADL scale (p = 0.041; ?b = 0.18), although C5a levels were not different from the control group. Discussion: AChR-ab titers and C5a levels could potentially be considered markers of severity in patients with MG.
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Palabras Clave
ANTI-ACETYLCHOLINE RECEPTOR ANTIBODIESMYASTHENIA GRAVISCOMPLEMENTCLINICAL SEVERITYBIOMARKERS
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