ARN de interferencia (ARNi): una herramienta eficaz en agrobiotecnología

Artículo

Autoría:

Gamero, Maira ; Tolosa Moreno, Deisy ; BELAICH, MARIANO NICOLAS ; Barrera, Gloria

Fecha:

2022

Editorial y Lugar de Edición:

Universidad Nacional de Colombia

Revista:

Revista Colombiana de Biotecnología, vol. 24 (pp. 1-9) - ISSN 0123-3475
Universidad Nacional de Colombia

ISSN:

0123-3475

Resumen

RNA interference (RNAi) is an evolutionarily conserved mechanism in most eukaryotic cells that allows genes to be silenced by degradation of messenger RNA (mRNA) and suppression of protein synthesis. In plants, RNAi molecules are involved in defense mechanisms against pathogens and transposons, in the adaptive response to stress, and in the expression of genes related to their growth. RNAi is an effective biotechnological tool to silence the expression of specific genes which are essential for the survival of phytopathogenic microorganisms, thus allowing the design of environmentally safe biopesticides with affinity and selectivity, in many cases greater than chemical pesticides. This review describes the latest advances in the application of RNAi in the agricultural context and its effectiveness in the biological control of phytopathogens and pest insects. Likewise, various experimental trials are presented, the results of which may be the basis for future bioproducts, as well as some examples available on the market. Finally, biosafety aspects and regulatory considerations necessary for the acceptance and use of this technology at a global level are presented.

Palabras Clave

APPLICATIONSGENESRNAiINSECTSPHYTOPATHOGENSBIOLOGICAL CONTROLPESTS

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http://hdl.handle.net/11336/201264