Producción CyT

Preclinical Study of Genuine ESSIAC Formula: A cancer treatment eight herbs tea minimizes DNA insult of X-rays.

Artículo

Autoría:

MARTINEZ MARIGNAC, VERONICA LUCRECIA ; Mondragon Leonel ; Oertlin Gloria ; Cervantes Lucia ; FERNANDA CANTERO ; Favant Jose Luis

Fecha:

2020

Editorial y Lugar de Edición:

Revista:

CLINICAL CANCER INVESTIGATION JOURNAL - ISSN 2278-1668
© Wolters Kluwer (India) Pvt Ltd

ISSN:

2278-1668

Resumen *

AbstractContext: Essiac tea is been used widely in the homeopathy market for cancer treatment. Aims: Wehypothesized its use for DNA‑damaged mitigation under very low ionizing radiation (IR) on BALB/cmice (10?40 mSv). Settings and Design: The radioprotection of Essiac tea formulae was evidenced by comet assay (CA) and micronucleus (MN) acridine orange staining. We also reported complete blood count, animal weight, and fasting glucose levels to control for tea toxicity. Materials and Methods: Fifty BALB/c male mice of 6-7 week old and pathogen free mice were randomly divided in to control group, control irradiated mice, irradiated and tea or ascorbic acid treated mice, tea treated mice and ascorbic acid treated mice. Genuine Essiac tea treatment was given ad libitum for 7 weeks and ascorbic for no >13 days. The animals were exposed to three different X‑ray doses (10 mSv, 20 mSv, and 40 mSv).Statistical Analysis Used: An independent one‑tailed t‑test or Dunnett?s test was used to compareanimal weight, fasting glucose levels, white blood count, comet percentage, and MN percentage,between doses, treatment, and controls, after a Welch?s ANOVA and Mann?Whitney U‑test using Excel worksheets from Biostathandbook.com website. Results: The tea formula resulted in a significant reduction of DNA damaged evidenced by CA (P < 0.01 for dose 3?40 mSv). By MN staining, the peak of significant induction of MNs by doses 1 and 2, P = 0.001 and P = 0.014, respectively, was not significantly different from controls when those irradiated animals were treated by tea. Conclusions:Using an optimized murine model, we demonstrated that Genuine Essiac tea is not toxic and that it acts as a radioprotector against very low doses of IR.Keywords: Cancer prevention, DNA damage, Essiac, reactive oxygen species scavenger, X‑rays Información suministrada por el agente en SIGEVA

Palabras Clave

DNA damageCancer preventionROSRayos XESSIAC