Producción CyT
Cold Spring Harbor Laboratory (CSHL) meeting - CSHL meeting – Systems Biology: Global Regulation of Gene Expression, Huntington, NY
Congreso
Autoría:
Rottenberg, Jaice T. ; Xing Liu ; Anna Berenson ; Clarissa Santoso ; David E. Hill ; Ryan Lane ; MARTINEZ CUESTA, LUCIA ; Marc Vidal ; Fuxman Bass, Juan I.Fecha:
2024Editorial y Lugar de Edición:
Cold Spring Harbor Laboratory (CSHL)Resumen *
To withstand a hostile cellular environment and replicate, viruses must sense, interpret, and respond to many internal and external cues. Retroviruses and DNA viruses can intercept these cues impinging on host transcription factors via cis-regulatory elements (CREs) in viral genomes, allowing them to sense and coordinate context-specific responses to varied signals. Here, we explore the characteristics of viral CREs, the classes of signals and host transcription factors that regulate them, and how this informs outcomes of viral replication, immune evasion, and latency. We propose that viral CREs constitute central hubs for signal integration from multiple pathways and that sequence variation between viral isolates can rapidly rewire sensing mechanisms, contributing to the variability observed in patient outcomes. Información suministrada por el agente en SIGEVAPalabras Clave
viraltranscription factorstranscriptioncis regulatory element