Producción CyT
Congreso
Autoría
MARURI, ALEJANDRO
;
Izeta E
;
Despuys G
;
Goldman A
;
Fenoy MI
Fecha
2023
Editorial y Lugar de Edición
Facultad de Ciencias Veterinarias UBA
Resumen
Información suministrada por el agente en
SIGEVA
Feline Leukemia Virus (FeLV) is a retrovirus thatsignificantly impacts domestic cats worldwide.FeLV can cause bone marrow suppression, leadingto anaemia and increasing the risk of secondaryinfectious diseases. Immune-mediated bonemarrow failure involves inefficient hematopoiesis,resulting from altered hematopoietic stem cellsand abnormal interactions with stromal cells.Mesenchymal stem cells (MSC) play a crucialrole in the bone marrow´s hematopoietic niche,potentially influencing hematopo...
Feline Leukemia Virus (FeLV) is a retrovirus thatsignificantly impacts domestic cats worldwide.FeLV can cause bone marrow suppression, leadingto anaemia and increasing the risk of secondaryinfectious diseases. Immune-mediated bonemarrow failure involves inefficient hematopoiesis,resulting from altered hematopoietic stem cellsand abnormal interactions with stromal cells.Mesenchymal stem cells (MSC) play a crucialrole in the bone marrow´s hematopoietic niche,potentially influencing hematopoiesis andimmune regulation. However, no documentedcases of MSC use in myelodysplastic syndromesin cats with FeLV. In this case report, we describethe treatment with allogeneic MSC in a 4-yearold mixed-breed cat with chronic anaemia anda positive FeLV result (detected by PCR in thebone marrow). The patient had non-regenerativenormocytic normochromic anaemia (hematocritof 18% and haemoglobin level of 6 g/dL) anderythroid hypoplasia with hemophagocytosisdue to a bone marrow response to an underlyingviral disease. Previously, the patient had beentreated with erythropoietin and prednisolonefor a year and a half, and blood transfusionshad been performed on several occasions whileattempting to reduce the prednisolone dosage. Inthis context, we proposed an immunomodulatorycell therapy, which involved the transplantation offresh allogeneic mesenchymal stem cells obtainedfrom the adipose tissue of a healthy donor. MSCwere isolated, in vitro cultured and administeredvia intravenous and intraosseous infusion undersedation. As a result, the patient showed a favourablerecovery, as reflected in monthly haematologicalevaluations indicating a progressive increase inhematocrit and haemoglobin values. After fivemonths, prednisolone was discontinued, and thehaematological values remained stable. At 17months, the patient remained off corticosteroidsand showed significant improvement, with ahematocrit of 38% and a haemoglobin level of14.5 g/dL. Based on the immunomodulatoryeffects of allogeneic mesenchymal stem cells, itis suggested that these cells may have modifiedthe bone marrow microenvironment, leading tothe normalization of hematopoiesis in this felinepatient with chronic anaemia and FeLV. Thesefindings open the door to future research andclinical applications of allogeneic mesenchymalstem cells in managing haematological disordersin cats and other species.
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Palabras Clave
felinemesenchymal stem cellsanaemia