Producción CyT
Congreso
Autoría
Aguirre F
;
Justo ME
;
Aldecoa M
;
Cores V
;
Leoni J
;
Villa A
;
PAZ, MARIELA LAURA
Fecha
2021
Editorial y Lugar de Edición
IOS Press
Resumen
Información suministrada por el agente en
SIGEVA
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies, whose production is T cell dependent. Regulation of autoreactive T cells depends on regulatory T lymphocytes (Treg), which have been shown functionally defectives in MG patients. Vitamin D (VitD) has immunomodulatory effects, stimulating Treg and inhibiting effector T cells. Previous studies have shown that vitamin D levels are low in patients with autoimmune diseases. However, few studies ...
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies, whose production is T cell dependent. Regulation of autoreactive T cells depends on regulatory T lymphocytes (Treg), which have been shown functionally defectives in MG patients. Vitamin D (VitD) has immunomodulatory effects, stimulating Treg and inhibiting effector T cells. Previous studies have shown that vitamin D levels are low in patients with autoimmune diseases. However, few studies have studied levels of vitamin D in autoimmune neuromuscular disorders.The aim of this study was to evaluate serum levels of 25(OH)VitD in patients with MG and healthy controls (hc) and the association of vitamin D levels with clinical severity of the disease.25-OH-VitD serum levels were evaluated in 66 MG patients and 25 age- and sex- matched healthy volunteers (hv), at the Ramos Mejia Hospital in Buenos Aires, Argentina. 25(OH)D levels were measured with chemiluminescence, samples were collected equally distributed through the year in both groups. The clinical status and MG severity were determined using ADL (Activities of Daily Living) and MG composite (MGC) scales. Sun exposure and vitamin D dietary intake have been assessed by locally adapted questionaires based on OPTIFORD project.Vitamin D deficiency (25(OH)D (<25 ng/mL) was observed in 83% of MG patients vs 56% in controls (p=0.02). No statistical difference was found in 25-OH-VitD mean serum levels in MG patients and hc according to the season of sampling. No statistical difference was found in 25-OH-VitD mean serum levels in MG patients and hc according to the season of sampling.A significant higher proportion of MG patients having nonsufficient levels of vitD compared to the control group was observed. However, when comparing 25(OH)D median serum levels between MG patients and HV, no statistically significant differences were found.We also found a weak association between vitD levels and the severity of the disease, according to ADL score.
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Palabras Clave
VITAMIN DMIASTENIA GRAVISACRA