Producción CyT
MEDICINA - CHARACTERIZATION OF Chlamydia trachomatis MALE UROGENITAL INFECTION: ASSESSMENT OF ASSOCIATED INFLAMMATORY RESPONSE, SPERM QUALITY AND MOLECULAR EPIDEMIOLOGY.
Congreso
Autoría:
PAIRA, DANIELA ANDREA ; Olivera Carolina ; Martinez Maria Sol ; Ferreyra Fernando N ; Molina Rosa I ; Tissera Andrea D ; Rivero Virginia E ; Saka Hector A ; Motrich Ruben DFecha:
2023Editorial y Lugar de Edición:
Andrés Esteban ZapataResumen *
Chlamydia trachomatis (CT) is the most prevalent sexually transmitted bacterial infection that has been widely described in women and the associated pathology, while male urogenital infection has been poorly studied. Herein, we analyzed the prevalence of urogenital infection and its impact on semen quality parameters and in inflammatory markers in patients. A cohort of 212 male patients, aged 20-49 years old, who attend a reproduction and andrology clinic with primary partner infertility or with lower urinary tract symptoms. Semen samples were collected by masturbation and semen analysis performed according to the WHO manual. Infections by CT, HPV, Mycoplasma hominis, HSV-1, HSV-2, Ureaplasma urealyticum, Trichomona vaginalis, Mycoplasma genitalium, Treponema pallidum and Neisseria gonorrhoeae were assessed by PCR. Semen quality parameters, ROS, inflammatory cytokines, subpopulations of leukocytes were analyzed. Statistical analysis was performed by Kruskal-Wallis test. The prevalence of CT infection was 32.1%, being found as mono-infection in 12.2% and as co-infection with other uropathogens in 19.9% of patients.Patients infected with CT alone or co-infection with other uropathogens showed neither significant alterations in most of the sperm quality parameters analyzed nor increased inflammatory biomarkers in semen. Noteworthy, It was observed that the presence of CT alone or co-infection with other uropathogens shows an inversely proportional relationship between ROS levels and the number of peroxidase-positive cells in semen. The presence of CT as a mono-infection produces an increase in the presence of CD8+ T lymphocytes, monocytes/macrophages and senescent T lymphocytes. The presence of CT with other uropathogens produces an increase in LT CD8+ and LB. Our results revealed a high prevalence of CT-infection in young men from our region. Although, CT infection does not significantly impair sperm quality, men would provide a reservoir for continuous transmission of the infection. Información suministrada por el agente en SIGEVAPalabras Clave
semeninfectionChlamydia trachomatisinflammation