Hypertension - Testosterone Supplements have Differential Effects on Blood Pressure in Old and Young Male Spontaneously Hypertensive Rats

Producción CyT

Congreso

Autoría

MARAÑÓN, RODRIGO OSCAR

Fecha

2015

Editorial y Lugar de Edición

Wolters Kluwer Health | Lippincott Williams & Wilkins

ISSN

0194-911x

Resumen Información suministrada por el agente en SIGEVA

Testosterone (?T?) supplementsare widely used by men to improve their quality of life, libido, and protectagainst osteoporosis. In clinicalstudies, both high and low ?T? levels were found to be associated withhypertension and cardiovascular risk. Endogenous ?T? levels are reduced in obese menand rats. We have shown previously that?T? supplements in middle-aged (6 mos) obese Zucker rats improved symptoms ofthe metabolic syndrome and caused weight loss, but increased their bloodpressure. How ?T? ... Testosterone (?T?) supplementsare widely used by men to improve their quality of life, libido, and protectagainst osteoporosis. In clinicalstudies, both high and low ?T? levels were found to be associated withhypertension and cardiovascular risk. Endogenous ?T? levels are reduced in obese menand rats. We have shown previously that?T? supplements in middle-aged (6 mos) obese Zucker rats improved symptoms ofthe metabolic syndrome and caused weight loss, but increased their bloodpressure. How ?T? supplements affecthypertensive men and rats is unknown. We hypothesized that ?T? supplements wouldfurther increase blood pressure (BP) in both old and young male spontaneouslyhypertensive rats (SHR). Old (O=20-22mos) and young (Y=10 wks) male SHR were treated with ?T? (testosterone propionate8 mg/10 mm silastic pellet; OT and YT, implanted sc) or placebo (empty pellets;OP and YP, sc). Pellets were changedevery 3 weeks for 8 weeks. Mean arterialpressure (MAP) was measured by telemetry for 2 weeks. MAP in OP was higher thanin YP (OP: 166±7 vs YP: 148±0.5 mmHg, p<0.001). As we predicted, ?T?increased MAP in YT (YP: 148±1 vs YT: 157±1 mmHg, p<0.001). In contrast, ?T? decreased MAP in OT (OP: 166±1vs OT: 155±1 mmHg, p<0.001). Thesedata suggest that in younger men, especially men who are already hypertensive,blood pressure should be monitored closely during ?T? supplementation in orderto prevent further cardiovascular disease. Since ?T? reduced MAP in older male SHR, thesedata suggest that ?T? supplements may not be as detrimental in older hypertensivemen as in young men. Future studies willneed to be done to determine the mechanisms by which ?T? increases BP in youngmales and the mechanisms by which ?T? reduces BP in old males. Supported byNIH-R01HL66072, PO1HL51971 (JFR), 14POST18640015 (ROM), EFF Endocrine Res Grant(LLY).

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Palabras Clave

HypertensionAgingTestosteroneMales