Comunidad CONICET
Investigador independiente
Especialidad
Biologia Celular y Molecular- Cancer
Disciplina Científica
Bioquímica y Biología Molecular
- Ciencias Médicas
Tema
MACROFAGOS INDUCEN RESISTENCIA ENDOCRINA EN CELULAS DE TUMORES DE MAMA
Lugar de Trabajo
CENTRO DE INVESTIGACIONES EN QUIMICA BIOLOGICA DE CORDOBA
(CIQUIBIC, CONICET-UNC)
Depende de
- CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS
- UNIVERSIDAD NACIONAL DE CORDOBA
- FACULTAD DE CIENCIAS QUIMICAS
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| AV. HAYA DE LA TORRE S/N, X5000HUA - Córdoba - Argentina |
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Resumen
Información suministrada por el agente en
SIGEVA
The Epithelial mesenchimal transition program depends on a series of intracellular signaling networks involving, among others ERK, MAPK, PI3K, and c-Fos. Previous to EMT, CD44low/CD24high cells correspond to the phenotype of the majority of cells found in breast carcinomas whereas a shift to CD44+/CD24- cells, promotes EMT and a profile associated with human breast cancer stem cells leading to the acquisition of mesenchymal qualities and an increased ability to form mammospheres and increased m...
The Epithelial mesenchimal transition program depends on a series of intracellular signaling networks involving, among others ERK, MAPK, PI3K, and c-Fos. Previous to EMT, CD44low/CD24high cells correspond to the phenotype of the majority of cells found in breast carcinomas whereas a shift to CD44+/CD24- cells, promotes EMT and a profile associated with human breast cancer stem cells leading to the acquisition of mesenchymal qualities and an increased ability to form mammospheres and increased metastatic potential.We found, that the microenvironment formed by macrophages induces both EMT in breast cancer cells with a stem cell?like phenotype and overexpression of c-Fos. Furthermore, in cultures, this microenvironment induces proliferation, invasiveness, and migration of these breast cancer cells, even in presence of Tamoxifen.. Furthermore, In vivo, this microenvironment increases breast tumor growth when macrophages are co-injected with MCF-7 cells into immunocompromised mice and Tamoxifen resistance.
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Líneas de Investigación
todas las lineas
Ciencias naturales y exactas
- Ciencias biológicas
- Bioquímica y biología molecular (ídem 3.1.10)
Capacidades Tecnológicas
6 - Ciencias biológicas
6.1 - Medicina, Salud humana
- 6.1.2 - Investigaciones clínicas, ensayos
- 6.1.10 - Investigaciones médicas
6.2 - Biología / Biotecnología
- 6.2.2 - Biología celular y molecular
- 6.2.4 - Ensayos in vitro, experimentos
- 6.2.6 - Diseño molecular
Palabras Clave
tumor microenvironmentcancer de mamamicromedioambiente tumoralmacrofagos asociados a tumores TAMEMTTAM tumor associated macrophagesBreast Cancer
Formación Académica
1999 - 2004
DR EN CIENCIAS QUIMICAS
FACULTAD DE CIENCIAS QUIMICAS, UNIVERSIDAD NACIONAL DE CORDOBA
1995 - 1999
LIC EN BIOQUIMICA CLINICA
UNIVERSIDAD NACIONAL DE CORDOBA
Director de:
DIEZ, MARCELA
Becarios
DIEZ, Marcela Becarios
Codirector de:
PERALTA, MARIA FLORENCIA
Carrera Investigador
ZANIN, JUAN PABLO
Becarios
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Producción CyT...
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